Originally Posted by Tom Stormcrowe

Yes, it can if you overtrain and build too much Quad mass and let the adductors and hip flexors atrophy in relation to the quads.

Excessive Quadriceps hypertrophy in relation to the butt muscles creates asymmetrical stress on the SI joint (Where the pelvis and spine meet), and can create debilitating pain. This can be addressed with balanced training and some specialized stretching routines.