Sure they will work on a road bike. You just need to use a shoe with a recessed cleat, like the Keen Commuters you have. I would recommend getting the eggbeater candy. The platform is nice for long rides when you have a shoe that is not super stiff. They are a tiny bit harder to get in and out of compared to the eggbeaters, but you get used to it quickly.
How do you like those keen's. I was thinking of trying them out this summer.