Thanks guys,

I should also add to this thread: I've also made a hardshell case from Ortlieb small parts and a Pelican box. It's held up quite well too. However I use my Osprey bags 10 times more often, just because they are less to lug around. I'm also a little concerned that if I did lay the bike down, the case would snap off of the rack jarring the hell out of my camera equipment and possibly sliding into traffic.