With padded cycling shorts, I really like non-slip saddles. It allows me to really lock down onto the saddle, to get more power to the pedals, and get my hamstrings into the motion a little bit more. If I'm not wearing padded shorts, then I prefer a slippery saddle, like on my mountain bike. That allows the outside of my pants to slide around on the saddle, instead of being locked onto the saddle and my own skin sliding against my shorts and undies.
I don't like creams at all, while I'm riding. Fresh air and ventilation while standing works better than lube, for me.