+1

I place the 15.4 widescreen laptop in an Ortlieb laptop sleeve (http://www.rei.com/product/764005) that then slips into the laptop sleeve of an Ogio backpack. I added extra velcro straps to have the laptop stay firmly against the back. The backpack has a spare jacket, hand towel, and bike kit. Somedays, I wear the backpack and ride to work; other days, I drop the backpack into a Delta pannier. Occasionally, I place the laptop in a Targus laptop carry bag and place that into the Delta Pannier. So far, no issues. I always shut the laptop completely off. Which of the above has worked best for me? Wearing the backpack on my back. I get off the bike and take the backpack into work.