From what I've found, typical cyclocross wheels are a little beefier and a little heavier. They are a little wider to accomodate wider tires. I would say you could use cyclocross wheels on the road with no problem, but I would hesitate to use road racing wheels on a cyclocross track. If not doing any cyclocross racing or off roading, a road racing wheel would work fine. I just don't think an expensive racing wheel intended for road use would be wise to use to race cyclocross.