I used to work at a surface coal mine that used some of the really huge earthmovers - tires ten to twelve feet in diameter. If you've heard a bike tire go at 100 psi, you can imagine what a ten-foot tire on a four-foot rim with tread two feet wide sounds like when it goes at 100 psi.
We never had an injury due to tires, but a few people die every year in the surface mining industry due to exploding tires - often due to welding on the rims without properly depressurizing the tire.