Originally Posted by
Spunderbungle
Ireland. We're pretty much decided on the Vienna to Budapest one. It has the advantages of going through three countries and also starting and ending in large cities with international airports

We're thinking 2 days in a spa in Budapest afterwards to recover.
A very good choice. It does get a bit hilly at some parts, but it's an international route with a great deal of infrastructure. Also, riding the other way from Vienna to Passau, is a very easy route as well. I know lots of grandparents that do that one, so that speaks for it's ease and comfort.