Going to the Smokies again - this time with my road bike. Last year we had only our cruisers and after seeing the 25 mile up-hill road to Cades Cove I was miffed that I didn't have it. The ride back down will be friggin' great - theres a 180 hairpin.
The 11 mile Cades Cove loop is a fun ride. It's a single lane, one-way road that is closed to traffic Wednesday and Saturday mornings. Cars can be bumper to bumper all the way around in high season.