Neutral: easy enough setup as long as you have a compressor ready, could not observe any significant weight / rotational weight saving
Pros: run really low tyre pressures, no more pinch flats (it's a magical feeling), dead easy to switch back to tubes
Cons: comparatively high maintenance. This requires explanation.
Pinch flats will be no more - so long as you maintain the amount of wet sealant in the tyres. It is also still possible to burp enough air out to get a complete flat, the likelihood of (and recovery from) which depends on the amount of wet sealant, your tyre pressure, and how big you're hucking. Re-inflation from a complete flat is near impossible w/o a compressor, so there's no way you're fixing it on the trail - bring a spare tube.
Maintaining the amount of wet sealant means regular sealant replacement (at least quarterly), means constant cost of sealant, and most likely you will need to go through the whole setup process each time. The process is not difficult, but personally I've only had to replace a tube maybe twice in a year.