Originally Posted by
Al1943
I ride with some 250+ pound guys and from what I've seen my recommendation is for a 36 spoke 3-cross wheel with double butted (DT Competition 2.0-1.8-2.0) spokes, Ultegra or 105 hub, and CXP33 or similar rim.
36H is a good start, but DT Revolution (2.0-1.5-2.0) on the NDS would be an even better match. That hub should give about 60-70% of the DS tension on the NDS. With that matched to the cross section of the thinner spoke you end up with a very evenly balanced wheel.
3X is a solid and conservative recommendation, but not as influential for wheel durability as spoke tension and spoke numbers.