Originally Posted by FLYcrash

Aside from causing brake reach challenges, a smaller wheel will bring everything closer to the ground, affecting handling and making pedal strike a bigger issue while turning. My personal opinion is that the effect on wheel strength is small compared to these issues.

A 700c wheel with Rhyno Lites, 36 spokes, and Big Apples, built well, sounds pretty darn tough to me.

The LHT, I know, uses ISO 559 (26" ) wheels on the sizes up to 54 cm. Don't know your size, but if you are a 54 cm or less, the LHT is purpose-built for the wheels you want. Judging from hearsay (I've never owned one), it would probably be a fantastic commuter/utility bike. The Big Dummy sure looks cool...like a pickup truck that you pedal!

I'd say it's not worth worrying about. People beat the crud out of 700c wheels and come up smiling all the time. Pick the frame you like best and can afford, spec the wheels for the recommended diameter and with stout, high quality parts, build it up nice and tight, and enjoy the ride!