I ride a Specialized Dolce Vita and I like it a lot.
While women generally have slightly longer legs and shorter torsos proportionately, we have more flexibility to make up for that, and ride "men's" frames comfortably. But our shoulders are significantly more narrow, requiring narrower handlebars. Also smaller hands, requiring shorter reach to the brakes. We also will be carrying more weight on our hands because of our boobies, and often want more padding under the bar tape.
As far as the frame, it doesn't need to be much different for men or women. Not nearly as different as a frame needs to be if you are asian vs. white. Shorter asians will mostly be those needing the jr. bikes, as they have the shortest legs proportionately, regardless of gender. One asian woman I know has basically one bike for her to choose without going custom, even though she is probably 5'1" or 5'2", as she wants to ride 700cs.