well I'm going from mid range Michelins to gatorskins so I'll be able to tell you if there is much of a difference. I ride enough and hard enough that I would notice a difference. The main reason I went with gatorskins is well I wanted to give them a shot and this bike is my commuter and my bike I normally ride.
I remember feeling a slight difference going between tires last time but this time I will pay attention to it more especially since I ride more I'll notice this more if it is in fact that big of a difference.