I voted "dunno" because I dunno what's comfortable for you.

One of my saddles is tilted up. One is level. One I haven't sat on in 3 months so I don't know how it's tilted. But they're all set to comfort, whichever tilt that involves.

My racing bike saddle (Selle San Marco Glamour) is tilted ever so slightly upward because I hate sliding forward.

Whatever works for you is where you set your saddle.