Am I going to be the first one to say that how your bike as a whole holds up to potholes, running off curbs, cracks, rough roads, etc. has a lot more to do with the wheelset than the frameset? I commute on a CX bike (Surly CC - which works great, thank you "overturn"), but you need a good stout wheetset with plenty of spokes to handle the kind of abuse you're talking about. My commuter currently has Mavic CXP 22 rims (Semi-deep section rim) laced with DT Swiss spokes and they are holding up well so far.

As far as the frame is concerned, any decent CX frameset should be able to take it; titanium and steel will hold up better and longer than aluminum; and get a frame that uses a traditional headset not an integrated one, especially if it's an aluminum frame.