Seconding this. Polk St. makes a lot more sense.

The trick, of course, is getting onto it from the Mission, given the impossibility of making (most) left turns off of Market.

North on Valencia, right on Market, immediate left merge into the (dual) left turn lanes for Franklin, left turn onto Franklin, right on Grove, left on Polk...

Polk to Vallejo, Vallejo to Franklin, Franklin all the way down to Greenwich/Chestnut/Whatever,and onwards to the Palace of Fine Arts.

The reason I have you take Franklin that last bit instead of Polk is it's synchronized green lights timed for 35-40mph traffic, and you can step into your tall gear and scream down into the Marina at the speed of the cars.

Polk is downhill and filled with stop signs. Recipe for pain.