I'm up to just about 2000 puncture free miles on a pair of Vredestein Spiders - slick centre, knobbles on sides, about 1.8". Puncture resistant layer (and having ridden over several broken bottles I'm happy). The knobbles don't touch the road when the tyres at near full pressure so roll well, unless you corner steeply. Off-road, I get plenty of traction on gravel, hard pack, sticky trails (I wouldn't use them in deep mud). Good on wet roads - the only time I've lost traction was on black ice. Wearing well.
Richard
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Currently riding an MTB with a split personality - commuting, touring, riding for the sake of riding, on or off road :)