I have both types of wheels. I really can't see an advantage either way. The high spoke count wheels are overall lighter and actually feel more responsive, especially when climbing. Unless you are pushing the limits of cycling or cycling fitness it really doesn't matter too much. Better to loose 5 lbs. from you gut than spend a lot of effort calculating the advantage of spoke count. The biggest advantage of low spoke count to me is the appearance. Someone ask me one time did I have a good ride and my answer was "No but I sure looked good doing it".
Disadvantage of low spoke count: Break one spoke and you are done for the day.