I do, and it's no problem as long as work doesn't suffer. I did a 50mi ride with a friend today in fact. The only hard times on my schedule are meetings, and most of those I can call into. I'm getting familiar with what service I can get where in Marin, which makes it easy to plan a meeting stop. I prepare by loading up the iPhone in advance with what I might need to have on hand (typically defect reports and tickets in my case).