Everything I've found, and the fact that there is more rubber in a bigger inner tube says otherwise. Used to get a bunch of pinch flats (around 2 per week) but no that I've switched to 2.0-2.5s I've had none. Puncture protection is probably a different, though, but more rubber should give you more protection, but thats probably like slightly rubbing brakes reducing efficiency. It might reduce efficiency in the lab, but in the real world, its almost unnoticeable. Still, I'll take the extra couple of grams for fewer pinch flats.