If you had mentioned Yonge & Eglinton, I would have suggested you take Finch -> Albion -> Weston -> Eglinton ->Yonge. Its pretty safe, and you skirt the 401 / Wilson / Albion / Weston interchange by going through a park along the Humber river.

The roads outside of Downtown Toronto can be really nice, but it still depends on where you are. Take a ride along Humber College Blvd to see what I mean (P.S.: I hope you don't have fillings in your teeth)