I have to pass through two areas with a lot of bars and nightclubs. The broken glass from idiots tossing beer bottles on the streets is the main culprit. I've tried the usual preventive methods (tire liners, slime, etc.) and nothing works 100% of the time. It has become easier just to fix the flat than to spend time trying to prevent them. I've become very good at fixing a flat in a hurry.

Unfortunately, there is not an easy way around these areas without adding a lot of time to my commute.