Suggestions I can make while not having done any real solo touring on my bike, but I have hiked the AT. Go light when it comes to cooking gear, alcohol stoves are one of my favorite ways to drop weight, invest in a good sleeping bag,down is great if kept dry, there are alot of nice synthetic fills out now that aren't very bulky though. And third think about if you really need a tent, I've done alot of hikes using a lightwight tarp set up, or used a hammock.
I'm planning a loop of SC in 09, ideally I'd say I'll be looking at 50 pounds less I get a trailer, then I might tote a few extras.