My problem is more at the base of my thumb. I went with larger, softer, ergo handlebar grips and Louis Garneau BioGel gloves and the combination helped a lot. Along with raising the height of my handlebars.
On my recumbents, I can ride for hours without the slightest hand/thumb pain. Don't even bother to wear gloves.
__________________
"Too often I would hear men boast of the miles covered that day, rarely of what they had seen." Louis L'Amour
There are two types of road bikers: bikers who are faster than me, and me. Bruce Cameron - Denver Post