I've been using Andiamo "Padded Skins" under regular shorts (or tights in cold weather) for my commute for about 6 months now. They're plenty comfortable, and they work well under jeans, too, for shorter rides where it's inconvenient to change at the end.

However, 6 months of daily commuting (~100 miles/week) have worn them out -- they have holes on the insides of the legs now. I'm going to keep them around for biking in "normal" clothes, but for the commute I'm switching to regular bike shorts.