When I got my first real road bike at age 26 I was a reasonably serious runner. 10 miles at 6:30 pace was easy.
My first ride was 6 miles and it kicked my behind.
Running muscles aren't cycling muscles. But in about three months I was doing 50 mile rides without much of a problem (other than not understanding that I needed to eat that is).
Aero wheels are great for training. They are usually stronger than non aero wheels.