Sure, why not? I run Gatorskins plus Mr. Tuffies and haven't gotten any flats since I started using that combo (I know, now I've cursed myself). I never got a huge amount of flats, and can fix them fairly quickly. But, it's something I'd rather not do if I can avoid it. On a purely recreactional bike, it's not that big of a deal. On a commuter, where time can be a factor, the less flats I have to deal with the better. Come to think of it, who wants to fix flats on a recreational ride? I'm willing to give up that *slight* performance edge in order to spend more time enjoying the ride, and less time on the side of the road...

Happy New Year, ride safe!