I have real doubts about using a trailer on anything other than a robust frame that is not going to go all noodly when the trailer is loaded.
The idea that it puts less stress on the bike's rear wheel is doubtful and defies logic. It just trades one set of forces for another set.
The only distinct advantage I can see is if you are using a bike that doesn't have braze-ons, such as an MTB with disc brakes.
There are also issues of having to carry additional spokes (replacement unlikely but it can happen), a spare tube, and perhaps a spare tyre.
I'd also suggest that with a fully-loaded trailer, moving the bike and trailer about by hand can become a significant issue, not just in terms of manoeuvring, but also in terms of balance.