I emailed Sheldon Brown that "I have installed a new Shimano R600 compact crank (34-50). It has a CBD of 110mm. I would like to replace the 50T ring with a 52T or 53T. Will the TA 110 Outer Chainring in 52 Teeth (CRT052), or 53 Teeth (CRT053) work, and any potential shifting problems? Any thoughts?"
His reply, "Yes, the TA rings will work. Shifting crispness may suffer slightly depending upon the shifters used. But the shifting performance will still be perfectly acceptable unless you are in elite level competition."