My right knee will probably require annual synvisc shots until they stop working and then it may be time for a knee replacement. But my ortho guy has patients who have been doing this routine for years, and they tend to maintain their effectiveness with repeated use. Let's hope so. This is from a 20 year old knee reconstruction and now it's getting increasingly arthritic. Last year within 2-3 weeks of the first shot I felt like I had a new knee. This year I can't even schedule the first shot until after the first race of the season (he's going on vacation soon).
Of course I'm hoping that ten years from now I can have some kind of more advanced cartilage replacement procedure (which is what I need, cartilage). That's sci-fi for now.