My Disc Rohloff hub is on a frame specifically built for it, but I'm going to retrofit my XC hardtail in the near future with a rohloff as well, so I've been researching this...
This handy thing solves chain tensioning on a disc frame with standard dropouts and a
standard bb shell, compatible with shimano hollowtech II cranks:
Tr!ckstuff Excentriker bottom bracket:
http://www.trickstuff.de/shop/produc...roducts_id=414
Get an OEM2 axle plate and a speedbone for your hub from a rohloff dealer
Get a frame that will allow for nice cable routing (if you have hydro guides for the rear disc you can zip-tie all three cables to it) and fits you and you're set! I'd recommend one with a gusset for the rear disc for extra strength
Oh, and if you don't have one, get a click box and a CC axle for faster-and-easier-than-derailleur wheel changes.