I always start the day with clean bike shorts. I never wear baggies -- they are hotter and don't dry as fast. During the summer I hand-wash the shorts in the restroom right after my shower. I always hang the shorts up during the workday to let them air dry. In the winter the humidity is low at my desk so they dry quickly; in the summer I aim a small fan at them to help them dry. I am prone to skin infections. My better-quality shorts have some kind of anti-microbe chamois so sometimes I don't wash them out at work. I wear the same pair of shorts home. In the winter I wear no-chamois tights over the shorts.