If you are using STI/Ergo, it does make a difference. With STI/Ergo you usually ride the hoods while with traditional pre-aero brake levers you ride the ramps so you are a few centimeters more forward with STI/Ergo. If you look at typical anatomic or ergo (or whatever) bars, the ramps are short and they bend sharply into the drop. If I were going to ride a traditional style bar with STI/Ergo I would probably want a shorter stem. The best compromise I've found is Deda anatomic bend. Even with those though the horizontal part of the flats is too short for my large hands and angled part of the bend causes too severe and a bend in my wrist that is uncomfortable for longer distances in the drops. I swear if I knew someone who made custome bars it would be worth the cost to have a few sets made to my specifications.