Get a saddle that fits. Test rides help. So do the various sit bone measuring devices. A saddle that is too wide, too narrow, or the wrong shape will hurt or cause chafing. Everyone's body is different, and there's no saddle that suits 'em all.

For me, it's a B-17S. I keep meaning to Proofhide it (especially after it spent two weeks locked up in the rain after I whacked my knee last fall), but I still haven't gotten around to it. Still comfy. If it's staying outside in rain, I do put a plastic bag over it. That keeps it reasonably dry. Since it's the most comfortable saddle I've used, I'm ok with babying it a little. Besides, sitting on a wet saddle isn't very comfortable.