YES. The first things I replaced on my Soho S were pedals and handlebars.

Just get pedals that aren't complete garbage like the Soho's. If you're running the bike primarily fixed gear, I might look into shorter cranks. But that's only if you're on the smaller side. As a short guy who rode the small size, I'd get tons of pedal strike with the stock 170mm cranks. Kind of stupid to put 170's on a frame that has a bit lower of a bottom bracket than most fixed gears. Other than that, you can go up from there. The wheels however lasted me a long time, and put up with a lot.

But I like the Soho S. It gets a bad rap, but it has a special place in my ssfg heart.