My B17 is tilted about the same, and was perfectly comfortable from mile 1. No break-in required.

If it were me (and I knew the height was good) I'd experiment with leaving the tilt alone and changing the fore/aft. You want your sit bones planted solidly on the flexiest part of the saddle. If you're on the metal rim, that'll hurt your butt, and if you're on the nose, that'll hurt your perineum.