I think you can make it work, but setting it up to get the chains to run smooth and getting the wheel straight may be a lot of trouble. Changing a tire will be more work. The bike will be heavier. There will be more friction. The single chain transfers the power well to start with. The power we humans put out is handled by one chain nicely.
The cog running the wrong way may come loose. Depending on the frame you may have clearance problems on the left side chainring to frame clearance. I don't see any mechanical benefit.
But, it will look cool, and everyone will ask about it! So try it and post pictures!