I prefer tall "traditional" frames, so on my favorite bikes, the top tube will brush against my jeans if I stand flat footed over the bike. Not enough pressure to be uncomfortable, but enough to be noticed. But, when riding these bikes, they fit me perfectly, and their longer headtubes make it easy to get the bars up where I like them (with the highest part of the bars level with the top of the saddle).
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I've read the "theory" that in an accident, having a smaller frame with a couple of inches of "stand over" space is safer than a tall frame with zero standover space. But, in "real life", any accident that sends a rider flying off the saddle onto the top tube is gonna hurt, whether the drop from the saddle to the top tube is five inches or whether it is ten inches.