What's wrong with CXP 22s?
What's so standard about Open Pro / Ultegra?
If you really want to upgrade why not:
1. CXP 33s
2. Moving from 14g to 14g /15g/14g or even to 15g like myself on the rear.
3. Moving from 14g to 15g or 15g/16g/15g on the front like myself.
4. 28/32 or 24/32
5. Carbon Kevlar Tires w/ Kevlar Bead in the 240-260g range assuming you have heavier tires.
There's lots you can do to bring down the centrifugal weight of your wheels for a performance gain without trying to be like Mike.
=8-)