Have you looked into the Terry Fly saddles? Allot of women in our club ride them and rave about them. Made in Italy..nice looking and well designed for women (and men) For your 45 miler, drink, drink, drink more than you think you should...maybe an electrolyte tab like Nuun and eat too. I like the little Gu cubes as opposed to gel for a quick boost.

Lastly..don't get caught up in the off the line adrenaline rush..start slow and easy to give your muscles a chance to warm up..you'll be thankful when you finish strong. I hope your wife is lovint that Roubaix pro...I have a Comp and have loved every mile on it..

Most of all..enjoy your ride!
PS..I'm illegally posting on the 50+ forum as I'm only 47..but like the group here! The club I ride with ranges from 20 somethings to quite a few 70+ somethings!

Have fun!

Tom..from Boston'ish.