Originally Posted by Jynx

I would go with a handbuilt set.

Rim: Kinlin XR-300. If you want a little lighter the XR-270. If you want even lighter Velocity Aerohead
Hubs: Dt Swiss 240s. If you want lighter get an Alchemy ELF front hub.
Spokes: Sapim CX Ray
Nipples: Brass Rear, Alloy Front
Lacing: 32 3X rear. 28 Radial Front. If you want lighter 28 2X rear and 24 radial front.

They will probably be about 200 grams lighter then what you have now and will be very reliable. The XR-300's may be slightly more aero but nothing drastic.