Jagged and Michel make good points, but they both come down to the fact the the best car route may not be the best bike route. Some people hate heavy traffic, but will put up with frequent stop signs on side streets. Others can deal with traffic, but hate being on roads with tons of stop signs. Some swear by bike lanes, others swear at bike lanes. Try various routes to work to see what works best for you.

Before your first commute, try the route on the weekend. That way you are less likely to get an unpleasant surpise when you have to get to work bya specific time.