It's always a combination of frame, fit, wheel set and tires. My often-posted Campy Carbon Ironman is tops. The stiff wheels balance out the flexy fork and it soaks up the bumps and the miles.
Waiting in the wings is the Centurion Cinelli Equipe, which will be lighter and ride tubular. Time will tell.
The finest riding bike I've ever owned, in any category but touring, I guess, would be a Pinarello Montello.