I wouldn't recommend the SA 8 for a bike with big wheels, though; the way it's geared, you'd have to use a tiny little chain ring, and it would look very strange.
Many cyclists would say it's the small wheels that look strange!
I surveyed 120 new models of Trek adult bicycle; 89 of them had from the factory "tiny little chainrings" that would produce a mainstream gear range with an SA8 hub.
Yes, these "tiny little chainrings" were the inner ring of a triple crank; still, I have to conclude small chainrings are common items and have wide acceptance in today's bike market.
tcs