If you can get them on the rim.
My latest theory on tires is foldable clinchers or whatever makes them easier to get on and off the rim.
I get so many punctures from thorns, tack weed, goatheads here in Eastern Washington, I'm almost ready to give up and settle for easier tire changes.
The foldable Conti gp 4000 is much easier to mount than the Gatorskin which thorns go through despite the purported toughness of the Gatorskin.
One of the LBS guys here claims he's ridden 4000 miles this summer on Vittoria somethings, green, without a single puncture. Maybe I should avoid ever riding a MUP.