I usually run my WTB Nano Raptors at about 70 for on-road use (I add 5 lbs to the max to compensate for my 205 lbs). I usually run 35-40 off road. Sounds like the cobble you ride on would be in the 50-55 lbs range for comfort/efficiency.
On my old bike I had a set of road-only wheels with Avocet slicks that I ran at 90-100 lbs....I really liked them for on road use.
Kev