I'm pretty stock as well Dnvr but let's see about these thoughts:

I guess my Look Pedals with the Q factor adjustment would qualify for an ergonomic adjustment so let's put those on the list. Also, I've been experimenting with different saddles and keep coming back to my Max Flite Trans Am. I've tried two different carbon saddles (including the SLR Gel) but those things are so stiff they wind up jarring these old bones pretty badly. I've dropped the air pressure a little in my front tire and seem to have a much more comfortable, enjoyable ride. I use a 44 cm handlebar which is much more comfortable for me than the 42's. And lastly, my 12-27 cassette along with my triple (52-42-30) allows me to spin up some of the steeper slopes without blowing out my legs!

In an "anti-ergo" adjustment I actually lowered my handlebars a little more to where I now have a little over 4" of difference in height between my handlebars and the saddle. I did a 80+ mile Sunday and it felt pretty good-even in the drops.....