Below are the finalists.
Rack Attack doesn't any of these assembled on the floor so there's no hands-on before buying which is an issue because my wife has very poor hand strength and needs to ascertain she can actually release the front trye mech when it's under tension.
We have a OneUp tray unit that's impossible for her to use. Plus it ain't fender friendly.
Has anyone any experience with racks listed below?
Am partial to the Kuat foot release.

https://rackattack.com/hitch-bike-ra...inch-bike-rack

https://rackattack.com/hitch-bike-ra...inch-bike-rack

https://rackattack.com/hitch-bike-ra...etallic-2-inch

https://rackattack.com/hitch-bike-ra...p-2-inch-black

Make sure your hitch actually comes out of its holder before ordering a hitch rack...

say what?

I don't have experience with any of those, but I have experience w/ my own Wife & my elderly Mother (not that your Wife is elderly). I'm tempted to suggest you find a place that has racks on display where she can manipulate them

None of those will be any easier or harder than the 1up release.

The Kuat foot release is for tilting the rack + bike outward, to clear a rear hatch while you have bikes on the rack. It does work, but you'll have to support the bike(s)+rack weight as you lower it.
The tire arm release is a large button up at the curved part of the arm, that fits on the tire.
These tire holding arms really don't work with fenders, but are easy to set and great for non-fender bikes.
~~
I like my Kuat Sherpa 2 for it's lighter weight. I thought it was about 30 lbs, but the specs say 42? I pull the locking pin on the hitch, loosen the clamp. I stand between the rack and the rear bumper, lift it free, and walk it a few steps to set it on a pair of large storage hooks on the garage wall. Easy. (I have a piece of white tape marking the tongue, so I know how far to insert it into the hitch receiver when putting it on the car.)

If you have an insert in your receiver make sure it's not rusted in. Common problem for people who leave inserts in.

Can you back that up with real world hands on experience? The designs above are certainly less awkward to manipulate than the O.U.

He thinks I didn't lube the receiver before penetration. Ha, not an old skin hound like me!

rum - not in this town.

rm - does it not also work to deploy rack from vertical to horizontal? All those racks above are similar to the ones on the transit busses I drove. While they work fool proof w/o fenders, they're perfectly serviceable with fenders.* I know, I schooled hundreds of commuters in their use during my career.
Not worried at all about on/off the car. I ride year 'round these parts it just lives on the car.

*Since my wife rarely, if ever, rides in the rain and never, ever, drives out to ride somewheres when it's raining I can just chop a little off the end of front fender so the stirrup is forward of the plane of the front axle. Is now as I sit here looking at it. Just.

Yes I owned the Thule T2 for a few years and have operated all of the other racks in your links because various friends have those same racks.

The whole idea with these racks is to hold the bike secure. So you have to press down with some force on the arms to hold the bike secure and whatever lever or button you have to use to disengage the arms from holding the tire will take a bit of strength / force as well.

On the Thule T2 I had to push the arm hook down onto the tire so that I could push the button to release it.

I have the Yakima Holdup and generally dislike it. The release pin to swing the rack up is awkwardly placed and becomes difficult to use when the rack has been exposed to the elements for a couple seasons. There's not really a way to lubricate it as far as I could tell. I do like how easy it adjusts to bikes of different wheel bases, you don't have to slide the rear tray, it hinges in place. It's easy to lock the front wheel in place with the hold down. The red release button becomes harder to activate the more force you apply to the tire, so you have to keep that in mind. It does an okay job with a full-fendered bike, but its not confidence inspiring when you have FULL full fenders, like Honjos or VO full fenders that stick way out from the fork crown. It wobbles when in the up position and is noisy. It has dropped to the "down" position before on a rough highway and once driving out of the neighborhood, so I use a safety pin now, making it even more of a pain to use. There are other reasons, unrelated to your question, that I dislike it.

The easiest rack I've ever used is the Kuat Piston Pro. The assistance might make it easier on your wife. But, of course, you'd be making a pretty significant jump in budget.

EDIT: I do like the built-in locks. I do not like how hard it gets to adjust the bike fore-aft position to clear a 2nd bike (wide MTB bars, for example), it's 4 hex keys to loosen it up to move and gets gunked up by exposure. I applied grease to it, but can't tell a difference in use.

I feel so out of touch with reality. Its not the Horror, its the Prices...

No kidding. I have a 1up rack and I feel I have been ripped off. Pretty expensive for a bunch of machined aluminum pieces that are bolted together. At best It's a $300 item in my mind. Not the $800 I paid. But what do you do? 1up and Quick R stuff make the best racks out there but they are never on sale and finding one used is next to impossible.

So my experience with my OU is that they used cheap plated bolts through the concave tyre holders and by the time I discovered it, one was irretrievably seized.
Plus it's a two handed op to release the mech - push tyre holding bar to release pressure while holding release trigger the entire time you're retracting the bar holding tyre, while bent over - making it awkward to release the 2nd wheel.
It's annoying. My wife hates the fuker.

Thanks all. It's either the Thule or the Kuat, whichever is lower to lift the bike onto.

I absolutely love my Sherpa rack. Light enough for my wife to lift, and easy enough to put the bikes on.

I got the Kuat Dock, and am able to slide my rack into it for storage on a wall.

Great stuff.

1UP ................................................. simple & solid

I'm shopping for rack to replace the Yakima I mentioned earlier and the One Up Heavy Duty is at the top of the list, so I'm appreciating your input on it. Despite the warts, I think I'm locked in on it because of the EZ Pull accessory. I need at least 3 trays and they're one of the only companies that I've found that have an option to allow you to release the pivot lock from the end of the rack, where you're lifting (the other being Quikr, but I can't really justify the additional cost). I have the 2 tray add-on for the Yakima and it's almost a 2 person job to change the rack position. At the end of a ride when I'm hot and exhausted, it is definitely a 2 person job.

Good to know about the bolting. I'll probably slather it in anti-seize until I can replace them with proper SS fasteners.

I wish One Up put the "one handed" release they have on the Xtreme Duty across the entire line. It's weird there's not even an optional upgrade.