Addiction LXXX
10-20-20, 05:02 PM
#2102
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Yes, tried multiple brands of dry and wet food, partly because of his preference but also to keep his digestive system happy. The neglected neighbor cat I have been feeding is happy to help me dispose of the food my cat won't eat.
10-20-20, 05:14 PM
#2103
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10-20-20, 05:27 PM
#2104
cowboy, steel horse, etc
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10-20-20, 05:30 PM
#2105
Should Be More Popular
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10-20-20, 05:33 PM
#2106
Klaatu..Verata..Necktie?
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The other day, when I got home from a ride and stopped recording on my Garmin, apparently I turned it on again, before turning it off again a very short time later.
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10-20-20, 05:35 PM
#2107
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Next!
10-20-20, 05:39 PM
#2108
Klaatu..Verata..Necktie?
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10-20-20, 05:41 PM
#2109
cowboy, steel horse, etc
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10-20-20, 05:42 PM
#2110
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10-20-20, 05:43 PM
#2111
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10-20-20, 05:43 PM
#2112
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10-20-20, 05:43 PM
#2113
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10-20-20, 06:17 PM
#2114
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10-20-20, 07:01 PM
#2115
shaken, not stirred.
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Hot Chocolate rest stop
While up at my parents I took dad's recumbent for a nice ride. Had to stop here and sample the chocolate. It was good.
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10-20-20, 07:11 PM
#2116
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My legs have been screaming at me this time home. I havnt don’t anything differently, and I am even riding less miles than before I moved but they won’t stop complaining. Today’s ride I purposely took it slow and just focused on spinning, 20 miles in I felt like I had ridden 60 miles. I ended up dialing up to get over this mound on monticello, and just kept it dialed up the rest of the way home. Felt good with the extra effort, but even now I am still feeling it.
10-20-20, 07:12 PM
#2117
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What I'm getting at is are two drugs such as Humira and Enbrel sufficiently different that the immune system responds to the second as if it had never seen an anti-TNF drug before? Or do the anti-bodies that someone develops for the first drug, which linger in the immune system memory, make it easier for someone to develop anti-bodies for the second?
10-20-20, 07:16 PM
#2118
So it is
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What I'm getting at is are two drugs such as Humira and Enbrel sufficiently different that the immune system responds to the second as if it had never seen an anti-TNF drug before? Or do the anti-bodies that someone develops for the first drug, which linger in the immune system memory, make it easier for someone to develop anti-bodies for the second?
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10-20-20, 07:59 PM
#2119
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Builds character.
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10-20-20, 08:14 PM
#2121
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What I'm getting at is are two drugs such as Humira and Enbrel sufficiently different that the immune system responds to the second as if it had never seen an anti-TNF drug before? Or do the anti-bodies that someone develops for the first drug, which linger in the immune system memory, make it easier for someone to develop anti-bodies for the second?
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"Don't take life so serious-it ain't nohow permanent."
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"Don't take life so serious-it ain't nohow permanent."
"Everybody's gotta be somewhere." - Eccles
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10-20-20, 08:16 PM
#2122
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10-20-20, 08:18 PM
#2123
Silver Comet Fred
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I have no complaints. @Velo Vol prolly can think of one. H'es prolly doing a time trial in the parking lot of the Brown Squirrel this wee'kend.
10-20-20, 08:28 PM
#2124
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That's my simplified lay mouse understanding of what I've read on why biologics lose their effectiveness over time. Whatever the exact physiological process, after X months, the joint inflammation gets increasingly worse to the point we decide it's time to try something else. (I took a couple of them that didn't help at all).
10-20-20, 08:32 PM
#2125
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The Brown Squirrel parking lot is too small. I'd go to the office park, ~2 miles to the northwest, for TT activities. It's about 1.2 miles per "loop."